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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770475222&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=GzJoCpuqOVIYNTANIoDPjIQ5i2GNhgsSJJEOY7BH-dNy0CBxV7CT8tizMolIYqQIA3CuGxesDbNHCbojJ2TsRwtMSelWoBotmwwN71ImW0GXloL59CTdFetgZ4BJUcjM9NRbL3OcCMNy093RpWHPjdJrpnh1InLmKp3XXeQ-rTORPKeCsumNcS2fv7-3TalqruFY0Wv4-xNY46H2RAPJ5kRmd1yLDjQ7jzIOLU9rbjJzAWQwZJCCjrUUaJ93m8aU6pGEJ2kCl4qoCUkz3Ghzuy8Zv7knDAWHplKjZjOKowTDrlDqF0gSNLcLHZ-w1lGhefxr-h-AHnKom6VlW8GMlQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770475222&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=a63qm1QhoCcigcENvYqjdLqZXhQNq-l0F9w6Elu6dz9iu5~zE9HFy4A6BMzLE4vWsCoUByogsYIHJrBGfTk83j5kJboCfGo2~GX-PsxyqOQmlf2tWf9Sfh~g7neHbgX3Zfi1DPyHBGgoSTYngNDdqEd8yVI1qRlPECvvBWdP4DAaF004ZBG9PJiK3kxVEVWYpxxCeOhoiHyEThOLvk4NR9hRMgDlnBzSJhQYU2Z42Hh0Xjc18W4OztvQq2MNNm~-CS8MZBW4f95~UvYemrtm5spXRZ9j-ncEWKet9SeyxZVX5CX6Q~p8h9KqeAvWfLChwd0BAcc6dstvKENcYMtHrA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger