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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086771&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=DchgWoD02rPu8P85edvRW1bEDT8QusJr~kGdjJr3cFAw4SJ3~wI-TV2DLiyYlYhwHXuXHOXdCl24yJMVC24Cq77738IUsyrt8yO8FxT2qfIfLsVl3e3gl7XM74GGh0PQsPVnk8fJP9HafbCIvw4JytBXbZzpgZ9pcNtKphVURNrrrpEil-FNe8r4~bK~qWj-ThJ-uPjtEHhts3yBhpSIs4NLjBeojlxcy6zbQgb9Nbjk4BT9fMQn6YZNw6HnsIxZo3wQydWfgMeK6rF8KcFHd8OkLvKmSj84L5PGJKKAiEsux7USze~1ihKdcOaPiSrz60kNWP78E4zIEOsfDTyx8w__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086771&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=NPhoT7ggFRfcqHATBn4mjupXxhMDkSFa-KiL8t9zRUlfkgpT6ozbKMxPAA69YnzMXbn7mr-erOL8yvIt05BOWwo2bDA7CILXLkU8P87w8oPF5ypXoOcZEpYXm6iHAfAXBF2f9qmnzmXIXeWbejZ2PL3gGE9JLo1qK-YuUSyqYl1DVCkHDEWtACMa9mw0FNKCEhoAJZFAMlkpGOqX2fu7zW4sv9A~3j1Q1eCgUQhACq3ateBbWNkX-M-R1LwThKdYLoUZha68ZSr7Grfcjb8srXh7PS3tBu06U~sFHlaGc26ZxdxvDXVgoG5ZaqaAUFF6xB2kP3HZtg910hORVpYOZQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger