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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774654622&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=XHwy0Dl6AbjQxTvd9pMZaK13b9gQfcrmTdWuthFRapNblJ7oJQmZGOeJGVIjo4d8yTsKbtAKctp3qXeqr7gmSdPERU8qVvVPiIpDFs3BgGTrVQJzDy4L7WTdy8czWIiNjpOlYNh~BdOiXvhbyPwf4XnehNHXSvVYErc7w0iFLmVrLCsyqBLjE2mte~XejzwN3mxLy2ROZdgP6E6o9vRdOQVbYaDdjZF5RMMh9iSQqDG1pjP7Tmj2xo52zbmuIPinHdgybqusq1kSgtEDO8h26JIQqSTwrq-b0vgK8aiArb34MkWVkrgin1mbIiuacwwehwWpGtQrZX7b7CtfhdmAmg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774654622&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=oOxxQhRr7~diUFicprgPZqa8yX-2ACBW4yhsG~aC~5FqAb4agpcmXaQxMsREez-I9UEz25EYSJqovWZ3rJ1-qaeWsNG88HBtWUgFdjYNPBImv5LdkP-BOvyoxq~31vxml26JKUEEt8QzT0opF4SCnGFe8BXoRhaQTVgSMBXJPni6r3AhvhAJ1nP5JO7Uc9l2kX6qP7XWUAjbyDlyaAptGmr4LR-Lj4ZeMcrZyQuqMM6IQlhtHj2BN6a6yxE8vU6sOPu9NxKVMU7xo6-L5FniyjkjJ6J1U5VpkjHQJ62JhI-lSSGWpge9FujtLrFJizryNLpZykNcySHL6k-xpYjWJQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger