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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480761&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=OLb~FQO3OiMMEKoRNku0TtHBs7tBI8voe3V0qxZgvfZCWbEj8enhJ-YHoGJrK2NXrvcl9PPcRBVqJGmC1OTkXwllu9mu~G7rSAypbG85yUYIaSev1~AJOeKdXlO3jxOln9Kg1JG09s9E4XUAHWefrbRoJxm44VXVuU9ATIP2~S7WvN6SK0l9v6CrPoFs6WvQk6e~QK8~gNDNgT~IvBfhDjUOOAkEefeJsMbSw2xXBUZYhVULrZVNbPLJayIAYYahxbnfHc~W33ynY5UR1mvVuTiMxWX37z9AZvfoMV6NtVaXNy5H2A-YivKL6PomsvK~vD56D83npz~hmaXaW4GH3g__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480761&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=HGn47WKl80SzyC6Ngzpvm0iTGMs8c0yVfWZEXwVN1vByZonhv4P7MVXNLWmtBuMOzNCEcnCT3sX2G5q1AGuILg4spt5ghVyxgoLXyxFotoEeOcJG42k~Ngw1bl~1zyYMsY1izHv8DO6JO4EHzJVgUFo2du~pOOpJIHaMDGIJDfujSM4im-pwA-YoJr0ksZCpVFE2cRwliGG0R7X2SZEg~9yth4ghZdjAKUeu0vlboMU9WCKUKJJatWxHMWPfHkn-WRD2t~aoJmGBIH~4Xqqsag14V9Q3EjSGVRUFvNH~4uIItSnoozwuR4zLQD4DnfUdRWlCXmV5HyFYqPpTifpXyw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger