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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770469937&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=jhPnB8suXB1PHWwFZk9IyQOm0naGYdlMrzjKPtBWSOboSEsi6izY58U3t3~Z1u4XanOzofrOUpigZQJbrZMCg-pd8o~PY~nOc8PX4J0HY~MLEcvD9axlcoG7HkSFYs2hateQjHL~4CM5jNyOQ7rfT50z7lQKG9q~1z8sd7Jpar3fsjPpsRXdMzmJpHmO7di5s5XMm7ieVQouzoFLAV3ZDPsbbvi2QYbvrzhaGGzAXeCpUCtSiFJDreDesh0OnIStaoHAApu-c6YGuVy2eCKi1TGmCvIgA6mT4-1l9o~p4RBWpeDTcQORKNMta~L1O5qt9ddGmHmdXDyrOfMtJuMw5w__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770469937&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=CiEEvS-dTtBGlYql95iK-g6H~b~6~b-3A19rSAOSKZYYZFi-65R7gE75K8iq7UzjQikDtChLjy7uTe6mGv~2nZj3dnzRzcQKsnTJ0N7joASOnayAPP-YJhFQEwrUpnk2i4Idib2JJZpg7LhyWDd~GO4ySqIrrCA7naoI6GbNsZ2STMclyld5dy1LJpr25nEqMN5Kr2ed90wdJPz4VYpo-WgTz5jhReEDYrQYTLtZ0ojg0QUOZ1nJ9xbigsxaFGiWnkxatCdglkyJcgCh6I4VA0exx4yTP4FqmlLUw4yY6JkkmTp1sz1LiU0Fk24SkaJxhb7dEbe07hX10tOLGBNJUw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger