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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765083895&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=cWFzm0VmqSg6OfRhz5K~U~XshygfoIvj973k814WqJ8IdYZZNJvpbp9JMk3OTuPsiNj2zr4n8OdaviQcQlaPzaYYnL0TqN-3wqHbooAgMYqjf0D~MKBxrsDfvJEwGtCryvAERtkkBHMtUnsqittY370ilfEdJ6f1wCkW0XintFJFE42pEExl1YZltERQTrYVDLSZ5lJawjZ59zBJmMW8ZUOaTixtcOwbyEgzLfYW7ihkCiiDeHjDUi8hADKWs2B9jjMSG8S61zmYnKPvMni4J0RomUrpG8g0rZt-QfIkTiXNnZ1IwDG4wK1Cf5LDL2CDdXbhZnehVS~935omK9W3ZA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765083895&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=GautaQWzqkZJKkZg36yIJn7H88qpzb30GYeYbgCZT9CGklZRqbNY6uIdxFsXCxw8~Sb3jc5j60UaaGbVclhWxiX~mWsKmryoysvuiLSmbfsSQvYHRAYcK5N1dqn27ovq9hDqofe7su3Ed9knNmFK3h7LGFhb3ZGT0XpmGWlhHjXkZRktICwPMO6Ke1BiIMjwPJk-1-HaHujRNu9TepqI4lz8WTUX1L1AK~F3h8b3qslwKdBV-bDIJuMAygzoEbugFrnchIpQ1O5Uzd9uAOyDWcB9Uz42FNlAzAMopy-8aZmPY1nr8F0NnKXDBS~Vnf3EbqRHTjyuLU2~~KiUXlLk3g__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger