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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774660935&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Ry1zJP7r3aSlZEfF07jZ-TYU2XVIUWS-U9mxCp7Vwsp3wLGgwreP3W1yG0hFADd7UlyaP~6sQIirkYWDhX5AI524y9taiUM1oSnvLfiHKpT7MGMpiFLLLTfKZmab5QPz807nPQyP3GcwIj6-WNaLsqc1AbVWNbNo85BBt7-zDVj9RRdDIX5gHAVpdCnEg5gDZ0cNFHAZrMDfj5bZ2xRPg6DGNjURyIab8HzfzQz3oqWWSF2o2eyDGznScjE23YSnJOCTFiYWv3hc9W5lac4ZD8Nz0PBMdxf79BFK38kqBkweK0f3zmW0ifyhTs-s4CDsmBY7O0m3Kpp2we69XjhBjw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774660935&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=ZY0WdQGLonOX2eTlA61s68YBIKIOR-CaZ0I4OdF6k8wkyHynNc0E2zsZQ3GQdR9fs-egfBfd5oJq0obCPNr11WxU6Bmh4re3ogCJH9EZ1v684YUMvz45jppy6GpJsFR9EjGw8HzHTe9iJ3YLBr4uf1HliHiHHTzib~GrlW6Gz-mK217fYYrtaSPA5Fo4w9FAvhVxkxr2ph45Tva09leEcMo7e3KpJHSWvwtTiU4MMtRaD~zIOkOmJu5kctihvOJepuLimHJhJhYpjj-6TN0KGZ7s4-LCmEWs4FGWzMB9oDkNgO3YAhR5y1K-LFfYEUEhbufaJXEt0iVSY0fhWjWNiA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger