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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480233&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=RoV8-tBDaGYocZRNvjmhf7rujJB5UPLg46~kZpKbK19UnIv7C630-WKy7b~zU1krW7cJeJYduCt2Sev8a--sam6~CXxFZR3jBpOArI4iYTOeWeHREBDzkRbkeu1UoDME9wsbUTUdyRI8TDLC1wfp75sq4ma2t4nI3U~PZpXO7Q2y75G3UUkoVoyJ11L0cEtI5zJUdrsMJU8RxHA7J7s4EgkfsCjSXPsb498BqmoPahputPRFF-ntrEUrpZxPrp5V7V9ZSqbZ5RaRInJ6pkwKg07Ouv6oM5KDgSh3hbFobh7Pa8lGxnPCXt4UfxeMnhq4bA5YBJoM0giEYnjMADtnEw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480233&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Sqt-TKgYSSUyREroPtthUqKbFT9W4lq-XJhYxzyJGHycBtYgbOR6h2d2EebM32zyIZ1OpxNzovxa~TKVuseiXdqQOTY6wh8~wie9qWbcqPkeeoznbQhmK0a1Pm7DchVVVatXWRHftqDJ4uyJZkrSb1DK6vW9i9UGjFDVXSZqN8n9FDigvRxcV7n2hjVYVDnUvP0JpSiTV~y6vFwtKEXywdW3doeEHK0gk~UZB~PQeZZpPidtQjdkHqqK~nWXwcI6v81lZGj6BfpZegAgucj1tdkwA8ZvKSxa6j5uyuukHr0YUKkcPTbg7IqZA~hSwY5yw~PjWPMqBh1X0ibwIl0Etg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger