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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774659662&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=NZxhTmzZmGsCii-gYqblF6zCbffkgSxt3URLI7hHYE7oeyDuILPs8QNX4Mg7r5RnsLT8XJcFB5UrZobUIWA5aeIns98Sy~lGkBKI3yiHtmQL8cByxuacj0v8JgdQFGEQV0u0L7au9-sVYKY0D-Idx7siCl6-1hrm2F~0dS0rYfce8ByRNaiNr40r-AyNke1ZN2yZz6CNQDViIRaMkDfQQMsq-cnZJnZICBHJ4CvYiyQOFAVQYx86TaBJ2qJenYrL5nssNe1MwfpvzenU40tw380sD8jkfdnh72BlEUlrQtlV7np~jEzRgQIA37MzMkx1jK8iIjTigSJ~qxf9EB~t0w__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774659662&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=d-2MSr60AQechXGQpyywyh1FW7lX8oo1L5kMQ7CCQlxOzqw7lGOOyUktxav7ewtay6p9qLtK4fHGaaj1sL3V4D4QxTp96woBcJ2d0Q14YzVBVI3Vcpabzon~PfJV5osdwqkPKfExfZx7JmPkO7qaPrp0bJNRkIlFs448-SXEWFMyFd0FtV58oNufqFDRE-7QLWTirVI4kh39qkAT1F2sZDgFPxFqsGjxn5hIdIUPivH6KhEEuKNPMX8OkmBNLaLJJfQC139xh1BuThjplX3b~xJGMkY7gL~AbZ5TGuY5XHPQnP~Anwf~EYtd-WIgoj87pAx-W8OryR~MkW2rzM7-1g__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger