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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086485&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=BVSW56kO7TrJooSlHRHcJ-GMxuhCNKRZuVB0T--hOcplNxs93kLFLhEEZEzsuTwmibDEcJHmb15FQmrZA2KAKqDM2D-lKuIKxboHzL-1ENoprgfcjFKgUcD~cfDsYxOJW7prq9FhwTfeHExbBJ8WRnIyBiy~Khxwy0mEYuJT5IlfblVBcl1wcqNMW~xw6zyNr~SoM7unBN68BcJ3M4Ahi6AJQMz6L68bmi5N39myUel6EUiJyPmX8MivH95iDfWzOq-rpgE1uKQDEcyNS39LkyNlkeAFTnD3VHopqBjgJtfmpvAQ4fgPskYQjJK6h6eh~G9g1-sy3dAGSn-qd0o9QA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086485&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=CVaGZLP47UspFl6-jqDoCkPM8H8W0eAyX4~mDUSxJeyd9SCkxaCscCi3qJ0OQ5~1veqNWjyD4fYTwSqYToExDSbuA6MdH2mo3VpakeP9kbG3PuoN9XKuOu8Yw5yHHIccCb-NqEqjtgJ6Yksu82O0cy66-d3J909lajOizE4TzNITXwVPashLcvDLgBf1OGQ5cjpJnf8tpLfHPc-DqDX2sUnO13iAuY80l-ECOlTGBaNs5x-nQ2zIZZReQwY~ujHWdOEvQVK4jEYUAII8bdAGWAsTf7ggLdbCJRZO6OvZqS4txQGBuvWuJXF3j5Voa9wg0NgnoZ9LUcqOL81-YTNUUw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger