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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770475064&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Pd1qM4Y4K0IW858EGmT2PPgUtBOeD5sZhRt-YOGLjuoc-pi-wUTDNdusSNJmThs9jApf4hvsEmjUikwOh6~M25tXsIneYsAqVhmpFXrR1TkJqFepjWweYquqlBdVbQto9RxtvG-kPqpjVaygPdbb-BwTLs6Hme2yyNiMayx18ECynRW3L4s75bzsSiUSGvOfXqAICBMhKc8nQkbbDP5SQzIrfE~ZbeEQfp884f7kC7k36lVhSZ7rRcgO--70XjOQZX2KSpqaj40PD98PFRzww3tDBFGnobOH7EVpYh0l5aCKRbzKB7UOV347Bofg8InpIQZrj8fhUPY7913v06yIYQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770475064&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=OeQHcsgR9cZlVcdLG~cmW9pIhvRL4vYpvp4ljAP4HWOR2V1tILyiM7FoIHswNz-zgpUu8YxuRAXmpGJqD1ybl5nSpqpFy8p1yKFXIcDqx9ywRxn1LSLslWE6FKUdKmbiJnogAnnk6QZZHSDkX2OX~32yJ3BGTxmWiNrFFTQxk1XsaJ07DLadbrg278ojgzI8U47tXMnFXBO3oRNCL8RTc8vWCgFQS6qoEh0U8iKy~i1OIJ3bpwuMHvOFDbx6jbOBiqMaWc~0UgxxxWwIxVYGZxILQAZ2G2ngurjlFyDgWxiSaREwcZQLaKmq92RokjBLGPJrfNXun-WLvg4ei5QNTQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger