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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765089572&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=fjJQGpJbuCF0R5rBvecyUxsKUkAg4gdPwjF3Oav~UJh3swfzpAyACzQVZXqcrvhaKAo1YUKQoUAWbvsJp~JUpZ8IyhNJy8f1r46GDVAwNxxEJRNGyJg2g60EdnYPOUOXncZu6Q-yx3M1RSvtcpIWNDfTjMf3TCuZesIfsyRI4ixS~PauZfhUhg2ae6RI57upHIhOX08T29vsTwY1GHUhuhWBdpJf01EoCNNQX-nYz1XgQmOb~vLKEsFEFmoWpzV4Ayl7H23zGeLg7Pc4qkxbtNvOAccoXgb~ILtfPSGw4EUzZbHhpOiziav5VLZeNEPxKYFqDVN5o-M1dZqc1lplKw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765089572&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=ZAXAl~TJehQu3NVdT0Af~uokiKNrDG~89cgXKX-AThMe3JrElSqL6cZZyoVfgKrT5-~C60nSQ~-0WEculWiVk~Rb9U5cc5KdsVFSPZLJTU0Rk0VXPlwJNdYWJ~OMEqz6fHk6U0bPJPiVARPaEox0taSp0p712Ja5jOT44elA9~UIUElT8SZXf12rJ3c1evsRcxvGQaEXcMgusRR2peVRFEzp5zU3yCqaGrefJl~p4EUmqSm3MVzfhBRng7fFReWGcx-90VN5nuqOFbU13taqqpL~~SZxhCxYQy4OY2DMRwzX0e56-tgm7w94~-i7tLbsKdt~3rqlix-ltChbdXslrQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger