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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770485598&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=fx7JwY3nrKm8GZ4StRlMiL4jdIPaSttAnbHo0uEgk5LXBKQX1xUX57C4FkGSulFtPEcl1Fg6QjrFRTQCXOZ~Km5wyWeMYUbUTFvKS7WPwgJ6~KYrwhQrlMpviA0Ayy2-M7AaeViFWTHQOiubNqaBgwk14MKux4Yo31sr4Kze6yoRkOy0H8Ji0xJDSBK3CGYES2fB-gb3uzoxBUc9X2zWJJvY0dQMYAmkx4GLfBoKxychKCspOUDKC~KkblyU98kDceqtQGnJ21t3KU3GM2kdeVq153FDDbKlXvz0KaraWGnBvqejaqfgtsoCk4QnnPXMvfqpgbFXABh4xjJqhy8LwQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770485598&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=A76xmo2pwWqNE--ZDIs6gWnAWkiUk-UYMUbubCSSEzEoGlMDtyJTZM9eW3H~jBuc4B~w-E9iRGAe-WOMmtJdxY8Bb1KZ-793yxPNM2uWHkQL9kNvYYFzoAw8pHQ3oIYm9xQz~AeXUsXxvKFdiZBfmYSXM3QJTIW23skCMXlRRK8PhF01pYcZpzxG9f5NR8D7QCvE3AoQ1mwwdZFcwFtu30NrkhD8gFdCBy74eXbd91kGxQgDQEyNtAO0D4GN9wpGDP-4IEpGzIm2zt9V3Luc3tbKbdNlbpo5hiEewl-nXEy3MrHeRnYO9ZZ0ekIam3rlG1zBwJ6khy18Z2-yU0NWCw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger