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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480441&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=n6fww2F38Lp4~mmAj3foFOg0tlGD8TbmPJa2wPmGPik6VVeMfL3~EqXIvP1bHpawJi2-dJT1n3FsFHn3GeQTZW5Inz~TKSkTZKvwze~VsR4DGpvqE41N2YaTz2DlIYjoCLGR3jP9JaXOa684fHlmEJvAajXm3Oa98TkcSgAY3Uwt7rxf0-4cADRCFMztqrlQITbdjtZB1DrBaulHGxv5xzudMMM-vF5-J10Zoal4rY5wns31AMRV~0kycmnxD7NThFbdtTkOUcSuIAACgcpeWev1qgxqefnni3vn79UCyxgxT~NqW2vanIWiJa87mS-VJ9SnASUmH0KnSH4AS1bcmw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480441&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=bLlytI1R0rIZUBni7DcJ8Ul6UW1xrnKo72fFCnD9UQLWYHtT7safmM500w5vn5tfR4aCI7GGCKJwYg-YICwj9Y5JcOtvmQujCoY~mfSTr2REfQXOoabUa8yCYOBI7aVYfog4s8s8~wvA252pUdf3v3aawh1CSJwasv~-Y6t~XqhDr3DnyWjQ38AGk3eF70Pe3lmWdRsmDhtJJuiPkHPyTOBAsxzVJPtbfSlbkidYcmNX22JghXnsf3LTkUcTc1EapzISCVOmwrgT07MyC5BUj4EgkWKEGaOfE-7ia22U9GrX5uskBCTLbp-GgqlObceebIoqNLURcXrwPN4zJI4Itg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger