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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774660931&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=FmF5I7ObfeZor2T9CPdVqarOdnJh~XFf4y~-ZRMGSSLJpnbl1zEHv1Izf8zYqTaqiYikMSKU9QXlVvWG1iqQTJj6NUivSPmfVCA8XXEcTq4nIwAvJTyZzjCLxgUcty1EohNZahu7qJdTg1NZFQOCvhzJYXqGmiCDwVCY1aYN~dThhHZ6Ur0~KL3m-rDgbFhyMxcuK9tR88PLhqBxU2hi2Pz9gXQSE~aL47PrH6DeXGXYLFP9jcFmGkRbguGHV9sGhJSLBprLRdZs3-qTLk5oUYIbcILBslN2NANVnTkFUQqDwF3fD4nPiad~L4J14eBk7UIU3Chx5Viwun69C4~9lQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774660931&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=e6W1Ad7Cl4Z99GFb9MuxZ8Sh58wsfSLjIzbId8NPPOb8ylaphYEBuBXxgpPDt5OaeYl0mUu-PswvKqOxKrJIEgNoMAhf88D1Hwlszmu4d8pCBG8edyXJJ0arWL6u~Z7emvmb7qnInPuZqDRPXdDebrWdbIyNKvSlP36cJesN-JfuOWsVepy1jTvWzUEcukI7cTrfK0wxCxmi3j~z~kiCnO7q0ez6MWIV1baHGWcVgE5ZC4WScJcnSYZLOIjnMp-fBEuN-zs6Gn9nMefwU6yfuoCWkcHpFwdQPF3no7HaqBz6-RT053I9KUtQjuuOcL8SXPZ2T20jlQr-485oFCYJXw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger