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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765090061&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=XJYTu9zmMgGIIunGgZY0pG~6u8Y2ilzFAnUWp28Q6MRH9tJMhv19zwcFQUAMNrfFPfsefWM9sc3NzzHWTXCg0Vsyewx7pacdwCTLYIGrM194sdTee0pjMW6kNdSZk0QaoUBXxF6TAycGXvPkxZOzq6LmrPPD0q0yEUJdBXdS5OisN8pUqmgO2tXHywqjL10mpoaVvE6JVl9SKuT92SNcq0gukXlfRThUuaoTMsBL0bH-g0m5HsSOax4wLrWP69hHGnPlJ7vVu39oWNvZ0ywPs1mRPPIM3IXF1U~QFx081T9BxUnG~WlvGWTAKSN70~W4Hps5kFLt-If8wRbRgDk02w__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765090061&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=VOx8DNjR~z6rvxMn2Tb~XUp7whRTEwlIO6IrpWcBgMdDlV1cVylHaNa7wUclCroauGk0Cy1dFox1uSG74hL2Z4fAzLHIMAiIQOBVjNkSrmp-De~R12DBtau~0MOSfSlqYqxieiE90HRU4kvOPjfy8uzPPyIqJvaxcAmVMQpbTka9W66UnTdQXZRfv3Pz1RN9goJHnMTo4hflQANVpWw9wYXocngupJMWD4-329q73XuA7RTMVAznTANwK6YqbcE4~v4FlF~JXRwtgPWbTbMv9OLYYFOJ9wa4MaV3NB8C~NHiFPGR1yIxQC0r4Mjz-lHPxofT7875IxkemUP5ROFQgg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger