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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086569&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=luZ26ExhXjvM4WbnD~DVKufeIMY2xu7ppL018FLlQjO4wF~WVfQZ8YpoeEVyrHG988H9TY2FKaJZ-z~ibq77Dx0rgY~LdR8LhKX2yW5GtbklSxpfmxmEtPsTccgUZU57e~pTgnPAmIPf0UYTzKhK0rWgrSppw0p8AVaxcZ6j4zdoAjTFBFkR-hlp44jKsm3i3bqSpEGohEeq9T716X0y8a1KFCdVO98J~XT2gUVo62rJ5QJY3kEzECzdBLWb9Ohn~6kTpqoz82HGbHRevLfJpq8sP8iCa926NxaWO6QRf43pgzz37lFNZH9d9i0uY6gTJobl~~8YYGupmg814t4VNQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086569&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=TdIovIPx73kc8YtHEpcVYd2MF-QQRBFOInLmqSCbpRm8pYy8M0QnMdqIdrnd5APLxhGD7SgHwCltK1WtX~-bRgEF15n-owBMhEUMVLCqiSzPsXzHKMmvl6Ne0PD2FdVmDB7ThH6gem2KSvvozba6N1e~nyyPSTWjMRQZ3~Z-PPb8Rm0h2mAely4lUJoLMJkjjLeN~SAXhmxF1Fv-v6pannaRkpMrtoTCBtLnS3hEjqzuN~oYuBMxR5g5-68HLVZwOkKNjoSBQuQfAUDJYih~qHzl7N3dLCmRQbXorMm8lClHMxbzcCIsyhh1dOo5W~HGwrFZ3etFCKQ7Beh4RcGbYA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger