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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774659752&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=FXQFQ7L7yLoEoc~s4aJLsKOW7GWYdC-7D-2RIHmfoqjembjCaSc2GWSD3sdBMJuUfwOVFqK~1qgl17HohSGeQslslhCLnEe2YcxM8d6BDGcMW~zS5BwL5scKMP~7u1OCpICGrI319XbTigr6DVQXboZQHAg3Vu9uilVFFV1A6O4Lu4YOBM6fq6vPyjHVdY3mW-HYgH4redv9sEboTdEn04es50MfoGUDd-O-mGPF-tI7vmeGK9wJK4EDvWZgXAPxwhRGm5FKKBkWLDvJV6Ff7dL~S3PTjqmwehw9CUp4IqPKwWGALZS7d6N-wQVrfvbWWIxbzFOKvHSVhLylDUJucw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774659752&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=WA6K7TKchwlUWehjsBzvciNU2gDsoHqhQKqlGFxe8zaAL2zqyPIz-t76rJhGjLxxTFrbu3XwKkuGCzt~9XJd91Ex82eo6Jnd~w3577RxIjUFLb~QbyMKdQgymyBzAvF8aftenJ1Z5tP7q-ErpDCFA7RCWJg6mJglz1iOUTzaygL77lT82ih6yH4tkyMYfBYmuWwtzgjT2rXiI78~O32tk2tkiXE5JhIYMkdl4xA3LPFnzF1KTmeuUiuLnsF3sEDVwKAd~CtCAmqZnv1VCBWhmUiuRo22HdvUtvUhzXgq7Ae~o-j4dQNy2uUbhP3irnyvIScobPLlafaJS7v-SUB5eg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger