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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480450&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=DM9gXYe--JfUldpp8-li~UE6tdkATmY73EFOH94b-NQsvxRGF9QKMiYEJKPRUUdu6LO~UL9CgbIBfFd07JdRdx10gjVN2YRknH5AncyROIXHoUkSfRHBmjIMmtuxVSiiks~QTSoeRRZ-yimUiu-UKnA1qwRUM~UBytNESuUu6gj6HemGAiD3IS7FnesgfyP8iGzIC~OLaV-zd3FafxYrXUOCxj8XYhdauTlcrlqhJfOd8wf8pAojMZug-2JyE5ehvZbC2EjENRowMGKPMUJ0Aive41tB1nbhoXJBp1EE9RXEYabCWcMrQSvfEmnBWz3eSka1lBZxDLVazilA96KtBQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480450&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Jptjs3vGDNfZD2GR2nO40kigx3gT9RM6JSL0RPGlnBuN7OxM6jQIWFGe71Mz7JJbWOjHdLYqVwn2yO03m1g-SzZKi3nLAhEs~k~4whaxC7TopIEV5m1bZy8S1~nIT6zu60OZuGjSqF3tXdBQI4VBsE4GAkddh9xIdGlgGIfENQDSSB0H-AQYm-N0tVQRXAWuoQvOtge9cjPJKW7u4Xfj-d-~nq4S3VDreT6g9lSpnUgb36WVv4b2UPZ~QUqrqNwZkqzXc0AEY1~I5T~-RZbiY7oO~jgQW7C1l9gud~n583F364nmAGLEEsp-519lBZU7~NwrIs4T7rluxjquDNZfHQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger