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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765089507&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=WndSMVwF-lnawzZNUj~W0w-3q~iB4jOgqooLpmrgJBhGRhZUqvcIWDS0DnVVAC213XFvSAdmhc3laUjdqal4UBRHT1YgqSZCfdVu1lqO8Bly~yN~K7b0DzeoOfBlaM7SGJ5ez~AiXze7ISiDvq4tw~f7VWob-ZHQwAsNXR0xKn-H7PXIe6Y5VCLXYErFLaf0qfyLHBSNySc9skIJAwZlgwbdVIGRwXvuvvB8mDU4KFIQ-yBypTycxGIbCl~zPRnpG~lI0HnlgtbRT9yCGjn5pwBCqenTOug794zxML4PVbuazYcO6kl4AJNdzMQN1uZ1gnqsnmnnAfZzJtrKhHoYmA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765089507&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=KopofjdxoWHP7MDQuKOOjM6sTqFDjXwcxTffN6QpY1C0rBvAZZkpN0E3ln4s6FR6H2o9whPcK5oLWYh6iaF64xpSU-9S9pA3NIjy5GWJlZbHAwG2DN6ZNlq7lkbdzwM1nAJPfSlnpoDWH7SOoK7ZNDX7wCiDIwp2KKbtDByPhbohB4cGvGAArtLyyn6BnPmCspW2XBsMYq7RGcP2bkiChs9jU5Sf9tFeslh5Mc0S6jc-gQmzbHfmo9Kzh6ZGikRVoqIPOmPUvTbbvCVVakO2TUPkxhI26gb9v0wkIM9qGeAzsscjuPqmi3BBrIVRKXgJt0SLYMvgGBNdDV2hopkyhQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger