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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774659753&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Ixbi-U1LmEKe4pxBlhVLfk57DlCjeHaTTiIlIrSaA4wRImpy9guklvTYT5Ad80srdG6MhbZdy2VYeOFq8lUDR2rTHLZIAPLO5p13bK7IkdjWKficPv57sjAtUSq1OG4Y~cnkgCln0N~0Tr8HSTRlnZYxoWs5emiPqFuRXw0DrezXRoMX~IIVtofa3vNA0mo7-ypRFVoVhfTezYRZjVTeC~Z2PEbIej88xPm7e3QbHY0kC7Kd0TOXij8aqLTkmY3sjdyRwEwxo6aEirL-r-2r2dO7NUz-UfbZdam8u5SGzVNqT33ZieHoBnnn64gbsEDxnm1HL9X4L8I-x5kBcfJEGg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774659753&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=R3gF-l2T-qOS3LX2AD6Vnv0ykHdLH9rpzebCyjoMtolwR~GPnpSeWefZHXIZIw8-wvZATf8s-CeVEZjBzxZKxqyHNEoDBN1RHlIeU4XYd4hEbnCQfCAWjOHfvlnsGpBSLERqG7Q3iSg4cctkOraNctOtWptxXUlPTy4wi3qxyqtAhKhw12J4YP49bApkgpWAvnsay9EnFa6kV0HPcpSGDYMedQppzqPjKI7LivvpRiGCorVmMae0pHTSnwxUFhuU3iB9KE4MRX0eQyNRJ-ZXSwGqLyi81rI0HAR3TEVUsJDBjE~cYtaPhFC0Cq8VsL389nSmA5lOuAvKi7S00OJqRw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger