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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480759&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=lLUnTaI3nl5OWexnoCN7B1kSD0diNRogg23xmIZiUgtpjCFJ0eeh-iAEkivO~ywPKgBHXdQtX3aWZ61jyE4OGzszGiBZ5zpwifbsqIMlkUVWpgs7ri7Hdv30-OibWbFawvVOgawxvAurBJSMcU6LAMDiEDPBljxbugrlVFW7AmRAlZU8-Ui05EpxxLUkvNjmoLYj-AOg8b4Ec1NhBbwrayicsODlaBz67FJv7THaZQRdloSof~a3AcO6pczcQVAPTcaIEHU7cKPVeQC3VDGhU8kES4oCvj6UN3S~fyXRQTIkUOY6e~Vh0YhAwG~9nsppLlwWZy5MkH8t3azznDjAiw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480759&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=old2ej0OCSKocTb4-xsxM0HU~5FkxdysJGTzKLVjQwI6VGzt7aHzoIR922ljduZrKezozMKR1jnpN8EqzlQOIAp4N~gx~1ENwW3VaodSrMIs3aiLzizakxVS2TTOSQd6dQktK2JdsI-E7DP8C0hwxX-443GgSvgGhkHqW6DLuXlgKsAHVIbdh2Jog62esOwl9hCnrU4tXQmq6zmGU8PVXf5YcpBf3FRcSjto4I9YM0DqHgvFh7n7f8ofdnO40oY~jIAmZH5QtBJgGGJXg0az11ac~Uiq0rYQ3HzM2YNAr~xdiQO0XqTxLYUF97k3KHnDwqsmZDyPGU6V8nHTLxYpcA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger