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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086765&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=lHoB4ZTHUi0Bn7rjtbqagSyvU2qb8HXpRubW02Oz~31y0qO3oEaDkEaHHO9K4jM2c9Wm1W2XVikUFPBTIwfVNYwvGYdDM8CnNutv3bQC4KP-ziqstQNDrRTYzC7Bt0wkBw4HjERrpUtiWoNoYqAZVxFp-kjfOoJd~UAjZIWI6UdTNy0nBCFYSjBEd-iA63sF2YQabThKRFu9J9h6a2PIKXu9XBVI1om28P3i4ojPzOLB5~~i718W0zg6b9wtWGp49V4wxtnSK92XUUbw5czKHgEFcAqX447oUhVcV6CV4s6TvRyMjGrbr4mzm2MxHvj2nabRQDdovJth9nIqOX06Uw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086765&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=NfNiAGCLOkktTTyogEatbbbFwxb3IoGwwh6-Bzrk2SM15CUcMhZvs2icEmTAG8QJkSMmRWrrJ6xnv~Tic7OvqSXtuRHUzJ6nhH4Kc2dkbg~LLqEC7885-WMBnRrAWPU30-Se7Dro2JP98nK0IzSQvNBDk5NLxGiAlUj7SqKP8pfI8C9qx~5Xs~R069wAVV5nf5yWSTtNePgJj4X3tDrr~Wn2lus~MTQSivObK-WTtI-tlZViaj-zQn7IB4LOTySjFMixGWmZYIg7ngHqXnrXLtZAEvVl0qBXOknp~IEy4LfwtwmjvD~o3iaD6c0cfG2mb3tClX8UJZrHFY66Ho32rA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger