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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774654619&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=nyWXA3P5YOzw--we3NFQIJLZ9JrNo4Hq8BN~9RF8flIxHN95ni6EClQqwEtP6pvCfHlsOilrBgXtqobzVNP0a7rn0vwkcku7m8FeHIwP14xpft3uF-3bA3rGlsdJdJUbCBBW5u-VKlaYqZKGl8ZLCnopsjVzF7c-0QKpGFbQNe7e7aBQ0gkULZfXQ5WIgm-PSpdkpO83fUpLGTA1zRPLwWQXmB3kpGkzNf5OYtLSS3VDHyM1X2LNhjP6AjI1nWZJfgfPc-Jr2JmAqifBOh1qg0gDRiGWdbi3E~WrMCJxrskzB8a~9kJV9dr~bpqL8AINHG1p7V3Y-87PZFSyPq1a7A__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774654619&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=WPUywA3U9G8Yk5pbHJLQu5eictsgrkK2-GESDs031cCdtzcnEJcjEymm~lqThK3SCYs0PpMyGXDFZlA6vOCfESbglCcuYuGwd-Wf6N33Pm7vCSiD3QJKMXK~Z8ZBCrNCJ--mqieBzqcA-aVGElLjtK3b~vxAaYVx-0OdfieTrR4ZXkjSX2Air9J8gm1oI1lFEdpfSJdBBW28Qz-l3QUAMmo3znKD8HxByrEVl9eHlfLI-KuWJ~8J9vnBebR4TB56EouEC69pS4Yac04LVdYA0hTX50cJV~hnaeQUiwYGFI4EdBx7lOEw1oX~nrvaBmnypt1APgAqXk6obMWGK5Olzg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger