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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774654621&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mmvYKUdLnd3jaU6RLCb1cGHAYlXXZn7p40LlFPoWccCyVdV1GnXJLbxkZL5JXrs-nx15YT9rU5tgnD84eab1j85Mm8xW7MYGSMdeAjdkp4BKRBR6M4GlRbJoWueM75UImOp33feCAPODgN9gij94FRfwkEHjpiGtv00VvwomFTiK8AaScFU6mwB1J6ukg2wx4DP4JkpXk0-s6DYdLoc4PlsaWBDwrgd5vdqZirajqrt1HZaF~CMtuqxpJTKPeMfrUxsqgH5Z0JT9KhBef4-alUP9FTcycmVcWhOVmXi~8C73MZACjLgD44~bHGNQvbxcujU2k5J5Ix0VDm3QPg-DBA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774654621&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=IQACtBh-mzch~QlEGe7FE6WNAud4W3fUvo9AQUPaT9ZXmVbQyzqTVsJJYI8sK4RKmUw5FC9~rj6ca08s6x16gALHDDSCAlP4ZU4QSf835me3CVayu7mXTEuFKUGkf6Iai8fTmYnWrad4tykokueJ7SpYfuGXZM30nSz5NyLrjjYmRpFx5aW4aCkSckrls0NvTsRovVZMowY0kLxh79mAc9wxi8~Xs7YYE3RrL0XfKSMQSCvF9GvHyPM9OhG84MgP4VR2KYntZyc~cEEOm2DkoIZ-uE79waQYghsMbdiJm7aKiXorxZpxWlMAJi45qWTrYJr2Y2xHF-yoNWrlobGgnQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger