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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774659584&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=O6gi~onEE0gi-cfvVCvmXfIeOG0aoqp~m66gmhF1g06H53pjh7-4XUjuA~EeYjtYfHIMN5ihKgkPPoZVV9fAHZzATTsvQzr5ilZc-SEAn-D8jE2u9R5bUy0PAGOPCpl6aoGaLwqvT3YFIwxMw-0F76IUyrIzXgEUlVATd4jCQVv8fEoO7JHaeVaJ5WHkQyo2jkeozkdnLthLmnePZVKWq5sfeC565vErocBea~WrxcPK8VhZ85s-Izf~J9962Cq~G4QEyHuCT0dEgsQpLNBU2ZZ3liw5KsH5UR6jhDLcEDDS326WSpKH1obmTDVcUHy6Y8YIQQ5K9b~usOfqeOp58A__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774659584&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=ZxuwXQcS-UMx2WKpCBNZxJR5FW3olYuFuPwRGaVW2WtOzpS9O0ie-i9P3~X~kYP5Idl0Ed8B459JyXAa8F9RmU08K7ZWDCBCNd3JNJPgabg8g3u4V8D8LcaELkmM7sIJKcHcIyRgW~scTMXJ3WwuCsM8mBoTxAOy5JpxNhOkosB3rG6YnITAXUnkoZN~qZed5MegFK9Rt0ssX1hvbwlHSPl68sSvRgSe-yMlh-9Fjifwf7YXaNVRzR3Oh70OusWBnd-VygA3rNHECfLR9JnbBAn3Gr8ymTfU8lSauAeSw5j9Fq1j01q0xv-F28E8V9r4d-sKs1RdUgrIo4XSJnED9g__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger