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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086797&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=OFCMnuF~nu5-h735AR6JRte3e~v1ROrFsUbQuUUbmrlJBWAeFecW7yLxpMyvYREuf5lrwFF-qISXEJhs3OxphP9hJy5NO6Tx7xQlMmlha7TTXKL7bTcfCt--1L9edEmKMgNefpZHcGCoUiqtTXR5u07Sq0T0XnDsT8StrfIpbH4QU1v-xhoGizVE3KPoeu9uxiZLzqaffcyquqnUfVMvHpe3n2kDADWOOVwdNBYNWrnreG4rRgD4F9rU0Rx1SrZUUEqF-Hwwdtlq-ozUNHrAND9LPDU1Oy9CsJNC1Z3cAfBa~Njr5cF~BPuZ7WoGQAFIkkmra7io1nQg0cSE2-MPFg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086797&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=gP1AWaUy1q0dHAJMO23-zMLe0Ah0jp3ETeKqOybkT5x~LMO07PrARNB3okDY7jGkI5kbVKjLsgqb5XhMYB1efvAfhPYTDYhWaiQjDCmv~9pHPKME0K76IPQPnqyCR5bcp~yocbZ29vuCtujtQ4xjkowPx7x2UfRYzk1TYlHMR72vJ06iUtqacVFt5qtQ8EA1jcM~wULLFtsKFk~XACte~5FphQd57mKu8RSh0WFhedA1RxhWaH1twZq5gs~gRy9sLe9saXYMt0r5OLTFXr2AoM3nR68VzVa53sX6vKOafR~uPVI7E9JG3VqH249K8xlt8bfpSwRSBJcNzXKAY3ZonA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger