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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770475217&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=LuoP-KTczznIR9t56ie0PuF8-T4qketj0fieGCE5cl5RRVwIpVFLy1013EnaD0sdG2pgE91WgNnbIppDxKmHR6yTagmQLAt9sTEdV164GLu6vhopc7RXQx05mX3el9Jb6lHl2W9PWNPBKJ25B9v9AgfbZvQf7O2vTtMp3TxdwZz0OaccmbPlUkcXSfeWq8qU8~F4JHTQLpgAHp1HCc5082eRWsxxsquSiG5Lbxqss320A1Hd9GJuOViDXGHLtOirk3J6IPrU3z8eJRQNIw3JClgHMPAM7vLLo9Cvmu2rfy1CZD1woe8dBN4HC3Dl5G-27Oq2pqJ6Zz3uInTuFgoCtA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770475217&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=iKYPl18cFIVdYPweMlLYrBI8cQRWM8xfyQydCfMJ2~iQmH6PsN0y~vtvKc04bZm-u6-bxNI3nae7OR1TuAIufGLcd1iTV2hZDs8HkuyNvFYrYRL1ANGkpJZ0FsZDpAVVjN0PMkpZ5hFnYL1tELkkW~xgev2WgZx-lYSLrgtdmkFFarfzaG66XgNHMTL2XocXDIXbXBBujJiBXoL6R4qy2FtK-vaGln1QgLmbc9mzW-tFT3cWi4lQVmM900rUjhS1whLN2pta7CfAW9MHYkg1dDXwc-N7ePkqirZMxbE1ShTt-4O2b28pj3mTVR5GCPH5iNGUJrE4WBoZWmWEDC6A4Q__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger